| SMAD3 — SMAD Family Member 3 | |
|---|---|
| Symbol | SMAD3 |
| Full Name | SMAD Family Member 3 |
| Chromosome | 15q22.33 |
| NCBI Gene | 4088 |
| Ensembl | ENSG00000166949 |
| OMIM | 603109 |
| UniProt | P84022 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Loeys-Dietz Syndrome |
| Expression | Brain, Lung, Heart, Blood vessels |
Smad3 — Smad Family Member 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SMAD3 encodes a transcription factor that is a central mediator of TGF-β (Transforming Growth Factor beta) signaling. SMAD3 forms complexes with SMAD4 and translocates to the nucleus to regulate target gene expression.
SMAD3 is a receptor-regulated SMAD (R-SMAD):
SMAD3 is implicated in AD pathogenesis:
TGF-β/SMAD3 signaling altered in AD brains
Regulates amyloid-beta metabolism neuroinflammation
Influences- Controls synaptic plasticity
In PD, SMAD3 signaling affects:
SMAD3 modulators are being explored for:
The study of Smad3 — Smad Family Member 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.