Srsf1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Protein Name** | SRSF1 (ASF/SF2) |
| **Gene** | [SRSF1](/genes/srsf1) |
| **UniProt ID** | [P07919](https://www.uniprot.org/uniprot/P07919) |
| **PDB ID** | [2M8D](https://www.rcsb.org/structure/2M8D), [4PWV](https://www.rcsb.org/structure/4PWV) |
| **Molecular Weight** | ~28 kDa (248 amino acids) |
| **Subcellular Localization** | Nucleus, nucleolus; shuttles between nucleus and cytoplasm |
| **Protein Family** | SR family of splicing factors |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions. [1]
SRSF1 contains two RNA recognition motifs (RRMs) at its N-terminus, connected by a hinge region, followed by an C-terminal RS domain (arginine/serine-rich) that is extensively phosphorylated. The RRMs bind to exonic splicing enhancers (ESEs) in pre-mRNA, while the RS domain mediates protein-protein interactions with other splicing factors and components of the spliceosome. [2]
SRSF1 is a prototypical SR protein that functions as an essential splicing factor: [3]
The study of Srsf1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. [4]
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. [5]
Additional evidence sources: [6] [7]
Liu et al. TDP-43 and SRSF1 interaction in neurodegeneration (2019). 2019. ↩︎
Izumi et al. SRSF1 dysfunction in ALS/FTD (2021). 2021. ↩︎
Boutz et al. Cellular functions of SR proteins (2007). 2007. ↩︎
Krainer et al. SR proteins in mRNA processing (2001). 2001. ↩︎
Black et al. [Alternative splicing in neurological disease (2003)](https://doi.org/10.1016/S0896-6273(03). 2003. ↩︎
Licatalosi et al. HITS-CLIP reveals key functions of SRSF1 (2012). 2012. ↩︎
Zhang et al. SRSF1 mutations in cancer and neurodegeneration (2018). 2018. ↩︎