| SERCA1 Protein — Sarco/Endoplasmic Reticulum Calcium ATPase 1 | |
|---|---|
| Gene | ATP2A1 |
| UniProt | O14983 |
| PDB | 6OIG |
| Mol. Weight | 110 kDa |
| Localization | Endoplasmic/sarcoplasmic reticulum membrane |
| Family | P-type ATPase (Ca2+ ATPase) family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Calcium Dysregulation |
SERCA1, encoded by the ATP2A1 gene, is a calcium ATPase that transports calcium from the cytosol into the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR)[1]. This protein is essential for maintaining ER calcium homeostasis and supporting proper protein folding, calcium signaling, and cellular survival. Dysregulation of SERCA function contributes to the calcium homeostasis defects observed in neurodegenerative diseases including Alzheimer's Disease and Parkinson's Disease[2].
SERCA1 is one of three SERCA isoforms (SERCA1-3). SERCA1 is primarily expressed in fast-twitch skeletal muscle, but the isoform is also present in neurons and other tissues[3].
The SERCA family belongs to the P-type ATPase superfamily and:
SERCA1 features:
Nature reviews. Mitochondrial DNA repair and neurodegeneration. Nature Reviews Neuroscience. 2010;11(5):301-315. ↩︎
DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. New England Journal of Medicine. 2003;348(26):2656-2668. ↩︎
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787-795. ↩︎