| PMCA1 Protein — Plasma Membrane Calcium ATPase 1 | |
|---|---|
| Gene | ATP2B1 |
| UniProt | P20020 |
| PDB | 6A95 |
| Mol. Weight | 127 kDa |
| Localization | Plasma membrane |
| Family | P-type ATPase (Ca2+ ATPase) family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Calcium Dysregulation |
PMCA1, encoded by the ATP2B1 gene, is a plasma membrane calcium ATPase that actively extrudes calcium from cells, maintaining the low cytosolic calcium concentrations essential for neuronal function[1]. Calcium dysregulation is a fundamental feature of neurodegenerative diseases, making PMCA1 a critical protein in understanding Alzheimer's Disease and Parkinson's Disease[2].
PMCA1 is one of four plasma membrane calcium ATPase isoforms (PMCA1-4). PMCA1 is widely expressed and is the predominant isoform in many tissues, including the brain[3].
The PMCA family belongs to the P-type ATPase superfamily, characterized by:
PMCA1 features:
PMCA1 is highly expressed in:
Nature reviews. Mitochondrial DNA repair and neurodegeneration. Nature Reviews Neuroscience. 2010;11(5):301-315. ↩︎
DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. New England Journal of Medicine. 2003;348(26):2656-2668. ↩︎
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787-795. ↩︎