| PMCA1 Protein — Plasma Membrane Calcium ATPase 1 | |
|---|---|
| Gene | [ATP2B1](/genes/atp2b1) |
| UniProt | P20020 |
| PDB | 6A95 |
| Mol. Weight | 127 kDa |
| Localization | Plasma membrane |
| Family | P-type ATPase (Ca2+ ATPase) family |
| Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), [Calcium Dysregulation](/diseases/neurons) |
PMCA1, encoded by the ATP2B1 gene, is a plasma membrane calcium ATPase that actively extrudes calcium from cells, maintaining the low cytosolic calcium concentrations essential for neuronal function[1]. Calcium dysregulation is a fundamental feature of neurodegenerative diseases, making PMCA1 a critical protein in understanding Alzheimer's Disease and Parkinson's Disease[2].
PMCA1 is one of four plasma membrane calcium ATPase isoforms (PMCA1-4). PMCA1 is widely expressed and is the predominant isoform in many tissues, including the brain[3].
The PMCA family belongs to the P-type ATPase superfamily, characterized by:
PMCA1 features:
PMCA1 is highly expressed in:
Nature reviews. Mitochondrial DNA repair and neurodegeneration. Nature Reviews Neuroscience. 2010. ↩︎
DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. New England Journal of Medicine. 2003. ↩︎
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006. ↩︎