Septin4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-protein
| Protein | |
|---|---|
| Name | SEPTIN4 Protein |
| Gene | SEPTIN4 (also known as ARTS, SEPT4) |
| UniProt ID | Q9NQW6 |
| Molecular Weight | 43 kDa |
| Subcellular Localization | Cytoplasm, Mitochondria, Cytoskeleton |
| Protein Family | Septin GTPase family |
| Associated Diseases | Parkinson's Disease, Multiple System Atrophy |
SEPTIN4 (Septin 4), also known as ARTS (Apoptosis-Related protein in TGF-β signaling), is a member of the septin GTPase family that plays crucial roles in apoptosis regulation, cytoskeletal organization, and ciliary function. SEPTIN4 has been implicated in Parkinson's disease and multiple system atrophy (MSA) due to its presence in Lewy bodies and its role in neuronal survival. The protein functions as a pro-apoptotic molecule that promotes cell death under specific stress conditions, and its dysregulation contributes to neurodegenerative processes.
SEPTIN4 has the characteristic septin domain architecture:
Septins form heterooligomeric complexes that assemble into filaments and rings, providing structural support and serving as diffusion barriers in cellular compartments.
SEPTIN4 participates in multiple cellular processes:
SEPTIN4 is expressed in various tissues including brain, lung, and testis, with particularly high expression in neuronal tissues.
SEPTIN4 is implicated in Parkinson's disease through several mechanisms:
In MSA:
Therapeutic strategies targeting SEPTIN4 are primarily research-based:
Research focuses on understanding the precise mechanisms and developing targeted therapeutic approaches.
The study of Septin4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] SEPTIN4 in Parkinson's disease and Lewy bodies. PMID:15800189
[2] Septins in apoptosis and cancer. PMID:18628956
[3] SEPTIN4 in multiple system atrophy. PMID:21414776
[4] Septin GTPases in neurodegeneration. PMID:24531075
[5] SEPT4/ARTS in neuronal apoptosis. PMID:26297620
[6] Lewy body composition and pathology. PMID:28495535