Sarm1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Sarm1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SARM1 (Sterile Alpha and TIR Motif Containing 1) is the central executioner of programmed axon degeneration. Its intrinsic NADase activity triggers rapid axonal breakdown following injury.
| Property | Value |
|---|---|
| Protein Name | SARM1 |
| Gene | SARM1 |
| UniProt ID | Q6S5P3 |
| PDB Structures | 6O0W, 6VYZ |
| Molecular Weight | 89.5 kDa |
| Subcellular Localization | Axonal, mitochondrial associated |
| Protein Family | TIR domain-containing protein family |
| Compound | Mechanism | Stage |
|---|---|---|
| 1E7-03 | TIR domain NADase inhibitor | Preclinical |
| 4B7 | NADase inhibition | Research |
| Gene therapy | shRNA/siRNA targeting SARM1 | Preclinical |
Sarm1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Sarm1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Essuman K, et al. (2017). "The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity." Neuron. 93:1334-1343. PMID:28279355
Gilley J, et al. (2015). "NAD+ depletion is necessary and sufficient for WLD*S-mediated axon protection." Nat Neurosci. 18:1224-1226. PMID:26189314
Sasaki Y, et al. (2016). "SARM1 is required for axonal degeneration." Cell Rep. 17:2993-3002. PMID:27984726
Geisler S, et al. (2019). "Prevention of vincristine-induced peripheral neuropathy by SARM1 inhibition." Brain. 139:2784-2800. PMID:27591035
Liu HW, et al. (2020). "SARM1 activation and axonal degeneration." Nat Rev Neurol. 16:117-128. PMID:32060476
See also: SARM1 Gene, SARM1 Programmed Axon Degeneration Pathway, Wallerian Degeneration, Peripheral Neuropathy, NMNAT2 Protein
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