RTN1 (Reticulon-1) is a member of the reticulon family of proteins localized primarily to the endoplasmic reticulum. In the nervous system, RTN1 is involved in ER shaping, membrane trafficking, and neuroprotection. Alternative splicing produces multiple isoforms with tissue-specific expression patterns.
Reticulon-1 (RTN1) is a member of the reticulon family of proteins primarily localized to the endoplasmic reticulum. It plays important roles in ER morphology, lipid metabolism, and has been implicated in neurodegenerative diseases. [1]
RTN proteins contain: [2]
RTN1 is predominantly expressed in brain, especially in neurons of the cerebral cortex, hippocampus, and cerebellum.
RTN1 interacts with:
He et al. RTN1 and ER stress in AD (2007). 2007. ↩︎
Di Scala et al. Reticulon proteins in neuronal survival (2015). 2015. ↩︎