RBM39 (RNA Binding Motif Protein 39), also known as CAPER, is a splicing coactivator and transcriptional coactivator. It plays important roles in alternative splicing, particularly of neuronal transcripts, and has been implicated in neurodegenerative diseases through its interactions with TDP-43 and FUS[1].
RBM39[1:1] is a protein of approximately 530 amino acids with a molecular weight of ~58 kDa. Key structural features include:
| Property | Value |
|---|---|
| Gene | RBM39 |
| Protein Name | RNA Binding Motif Protein 39 (CAPER) |
| UniProt | Q14416 |
| Molecular Weight | ~58 kDa |
| Length | 530 amino acids |
| Subcellular Localization | Nucleus |
| Protein Family | RRM family |
RBM39/CAPER functions as:
RBM39 is implicated in:
Dowhan DH et al. RBM39/CAPER in transcriptional regulation and alternative splicing. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms. 2010. ↩︎ ↩︎
Dormann D, et al. ALS-associated fused in sarcoma (FUS) mutations trigger stress granule formation. Human Molecular Genetics. 2010. ↩︎