RBM17 (RNA Binding Motif Protein 17), also known as SPF45, is a splicing factor involved in the regulation of alternative splicing. It plays important roles in neuronal development and has been implicated in neurodegeneration through its regulation of disease-related splicing events.
RBM17 is a protein of approximately 420 amino acids with a molecular weight of ~45 kDa. Key structural features include:
- RRM domain: RNA recognition motif for RNA binding
- RG-rich region: Arginine/glycine-rich domain for protein interactions
- Splicing regulatory domains: Regions involved in splice site selection
| Property |
Value |
| Gene |
RBM17 |
| Protein Name |
RNA Binding Motif Protein 17 (SPF45) |
| UniProt |
Q96EB6 |
| Molecular Weight |
~45 kDa |
| Length |
420 amino acids |
| Subcellular Localization |
Nucleus |
| Protein Family |
RRM family |
RBM17 participates in:
- Alternative splicing regulation: Modulates inclusion/exclusion of specific exons
- Spliceosome assembly: Component of the splicing machinery
- Neuronal splicing: Regulates neuronal transcript isoforms
- DNA damage response: Involved in splicing-coupled DNA repair
RBM17 dysfunction is associated with:
- Alzheimer's disease: Altered splicing of tau exon 10 (4R/3R tau ratio)
- Amyotrophic lateral sclerosis: Dysregulated splicing of FUS and TDP-43 targets
- Frontotemporal dementia: Abnormal RNA processing
- Overexpression in multiple cancers
- Alternative splicing of apoptotic genes
- Therapeutic target consideration
- Splice-modulating oligonucleotides targeting RBM17-regulated exons
- Small molecule splicing modulators
- Combination approaches with other splicing factors
- Alternative Splicing in Neurodegeneration
- RNA Splicing
- RBM25 Protein
- SRRM4 Protein
- FUS Protein