| POLE | |
|---|---|
| Gene | POLE |
| UniProt | Q07864 |
| PDB | 6WNS, 6WOT, 5VBN |
| Mol. Weight | 261 kDa |
| Localization | Nucleus |
| Family | DNA polymerase B family |
| Diseases | Alzheimer's Disease, Parkinson's Disease, FILS Syndrome |
Pole Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLE is a protein encoded by the POLE gene. It belongs to the DNA polymerase B family family and has a molecular weight of approximately 261 kDa. This protein is localized to Nucleus and plays a significant role in the pathogenesis of Alzheimer's Disease, Parkinson's Disease, FILS Syndrome.
POLE has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: 6WNS, 6WOT, 5VBN.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, POLE performs essential functions in the nervous system. It is primarily found in Nucleus and contributes to normal cellular homeostasis, signaling, and neuronal function.
POLE is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of POLE contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
POLE represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Pole Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.