Pold2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLD2 (DNA Polymerase Delta Subunit 2) is the p50 subunit of DNA polymerase delta (Pol δ), a crucial enzyme complex involved in DNA replication and repair. The POLD2 protein forms the central scaffold of the Pol δ heterotrimer, essential for its processivity and function.
| Attribute | Value |
|---|---|
| Gene | POLD2 |
| Protein Name | DNA Polymerase Delta Subunit 2 (p50) |
| UniProt | P28340 |
| Molecular Weight | ~50 kDa |
| Length | 466 amino acids |
| Cellular Localization | Nucleus |
| Protein Complex | DNA Polymerase Delta (POLD1/POLD2/POLD3/POLD4) |
POLD2 contains:
POLD2 serves as a structural scaffold that:
POLD2 is essential for lagging strand DNA synthesis:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Impaired Pol δ function leads to neuronal genome instability; accumulation of DNA damage | PMID: 32067123 |
| Parkinson's Disease | Defective DNA repair sensitizes dopaminergic neurons to environmental toxins | PMID: 23467 |
| Amyotrophic Lateral Sclerosis | Oxidative DNA damage accumulation | PMID: 31199215 |
Altered POLD2 expression is found in various cancers, affecting genome stability.
POLD2 is being explored as:
The study of Pold2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.