| POLD1 — DNA Polymerase Delta 1 | |
|---|---|
| Symbol | POLD1 |
| Full Name | DNA Polymerase Delta 1 |
| Chromosome | 19q13.3 |
| NCBI Gene | 5781 |
| Ensembl | ENSG00000062822 |
| OMIM | 174761 |
| UniProt | P28340 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Colorectal Cancer, MDDP Syndrome |
| Expression | Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra |
| Key Mutations | |
Pold1 — Dna Polymerase Delta 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLD1 (DNA Polymerase Delta 1) is a gene located on chromosome 19q13.3 that plays a critical role in neurodegenerative disease. Mutations in POLD1 are associated with Alzheimer's Disease, Parkinson's Disease, Colorectal Cancer, MDDP Syndrome. The gene is catalogued as NCBI Gene ID 5781 and OMIM 174761.
The POLD1 gene encodes a protein that is expressed in multiple brain regions including Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra. The normal function of this gene product is essential for neuronal health and survival.
Expression data is available from the Allen Human Brain Atlas.
POLD1 mutations are linked to the following neurodegenerative conditions:
Publication list pending enrichment from PubMed.
The study of Pold1 — Dna Polymerase Delta 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki gene database. Last updated: 2026-02-26.