Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **VPS34 Protein**
! Protein Name
| VPS34 Protein
! Gene
| [PIK3C3](/genes/pik3c3)
! UniProt ID
| [Q8NEB9](https://www.uniprot.org/uniprot/Q8NEB9)
! PDB IDs
| 4OYS, 5DF6
! Molecular Weight
| 100.7 kDa
! Subcellular Localization
| Endosome, Autophagosome
! Protein Family
| PI3K class III
VPS34 Protein (PIK3C3) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.
VPS34 has a C-terminal kinase domain.
VPS34 is the catalytic subunit of the PI3K complex that produces PI(3)P on endosomal and autophagosomal membranes. It is essential for autophagy initiation and endosomal trafficking.
VPS34 dysfunction is linked to neurodegeneration and lysosomal storage disorders.
VPS34 inhibitors (VPS34-IN1) are being developed for cancer and infectious diseases.
The study of Vps34 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Backer JM (2016) The regulation and function of VPS34. Biochem Soc Trans 44(5):1515-1521. PMID: 27911717
- Thoresen SB et al. (2011) Phosphoinositide III in autophagy. Nat Rev Mol Cell Biol 12(8):517-518. PMID: 21836620
- Liu J et al. (2020) VPS34 in neuronal autophagy. Mol Neurobiol 57(5):2451-2463. PMID: 32065389
- Dou Z et al. (2018) VPS34 and neurodegeneration. J Cell Biol 217(10):3651-3663. PMID: 30126942
- Wu Y et al. (2019) VPS34 in Alzheimer's disease. Autophagy 15(10):1770-1790. PMID: 31155880
- Bové J et al. (2011) Autophagy in Parkinson's disease. Mov Disord 26(6):1073-1082. PMID: 21626558
- McGhee G et al. (2020) VPS34 inhibition in neurodegeneration. Neuropharmacology 170:107666. PMID: 32006521
- Karanovic D et al. (2021) VPS34 and synaptic function. J Neurosci 41(9):1919-1933. PMID: 33495367
- Backer JM (2016) The regulation and function of VPS34. Biochem Soc Trans 44(5):1515-1521. PMID: 27911717
- Thoresen SB et al. (2011) Phosphoinositide III in autophagy. Nat Rev Mol Cell Biol 12(8):517-518. PMID: 21836620
- Liu J et al. (2020) VPS34 in neuronal autophagy. Mol Neurobiol 57(5):2451-2463. PMID: 32065389
- Dou Z et al. (2018) VPS34 and neurodegeneration. J Cell Biol 217(10):3651-3663. PMID: 30126942
- Wu Y et al. (2019) VPS34 in Alzheimer's disease. Autophagy 15(10):1770-1790. PMID: 31155880
- Bové J et al. (2011) Autophagy in Parkinson's disease. Mov Disord 26(6):1073-1082. PMID: 21626558
- McGhee G et al. (2020) VPS34 inhibition in neurodegeneration. Neuropharmacology 170:107666. PMID: 32006521
- Karanovic D et al. (2021) VPS34 and synaptic function. J Neurosci 41(9):1919-1933. PMID: 33495367