Pde4C Protein — Phosphodiesterase 4C is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Phosphodiesterase 4C |
| Gene | PDE4C |
| UniProt ID | Q08431 |
| Molecular Weight | ~68 kDa |
| Subcellular Localization | Cytoplasm, neuronal processes |
| Protein Family | Phosphodiesterase type 4 |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
family (cAMP-specific) |
| Expression | Brain, lung, testis |
PDE4C is a member of the phosphodiesterase type 4 family, which specifically hydrolyzes cyclic adenosine monophosphate (cAMP). The protein contains an N-terminal upstream conserved region (UCR) that regulates activity and a C-terminal catalytic domain [1].
PDE4C is one of four PDE4 subtypes (PDE4A-D), each with distinct localization and regulation.
cAMP Hydrolysis: Degrades cAMP, terminating signaling cascades involved in learning, memory, and mood regulation
Synaptic Plasticity: Regulates cAMP levels at synapses, influencing long-term potentiation and depression
Inflammatory Response: Controls cAMP-mediated immune cell activation
Circadian Rhythm: Contributes to cAMP oscillations in suprachiasmatic nucleus
Cytoskeletal Regulation: Modulates actin dynamics through cAMP-dependent signaling
PDE4 inhibitors are clinically important:
The study of Pde4C Protein — Phosphodiesterase 4C has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.