Pbx3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PBX3 (Pre-B-cell Leukemia Homeobox 3) is a homeodomain transcription factor belonging to the TALE (Three Amino Acid Loop Extension) family. PBX proteins function as cofactors for HOX proteins and play important roles in development and cellular differentiation. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Protein Name | Pre-B-cell Leukemia Homeobox 3 | [4]
| Gene | PBX3 | [5]
| UniProt ID | P40417 | [6]
| Molecular Weight | ~47 kDa | [7]
| Structure | TALE homeodomain |
| Subcellular Localization | Nucleus |
PBX3 contains:
PBX3 is being explored as:
The study of Pbx3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Thorsteinsdottir et al. PBX in leukemogenesis (2004). 2004. ↩︎
Greggio et al. PBX transcription factors in neural patterning (2015). 2015. ↩︎
Miano et al. PBX gene family in development (2016). 2016. ↩︎