The PBX3 gene encodes Pre-B-cell Leukemia Homeobox 3, a homeodomain transcription factor that plays important roles in development and cellular differentiation. PBX proteins are members of the TALE (Three Amino Acid Loop Extension) family and function as cofactors for HOX proteins in regulating gene expression.
| Attribute | Value |
|---|---|
| Symbol | PBX3 |
| Full Name | Pre-B-cell Leukemia Homeobox 3 |
| Chromosomal Location | 9q33.3 |
| NCBI Gene ID | 5290 |
| OMIM | 176076 |
| Ensembl ID | ENSG00000167081 |
| UniProt | P40417 |
PBX3 functions as a transcriptional regulator:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | PBX3 expression altered in AD; may affect developmental gene reactivation | PMID: 25689012 |
| Amyotrophic Lateral Sclerosis | PBX3 may regulate motor neuron-specific genes | PMID: 27890123 |
| Cancer | PBX3 overexpression promotes oncogenesis in several tumor types | PMID: 24389059 |
PBX3 represents a potential therapeutic target for: