| Occludin Protein | |
|---|---|
| Protein Name | Occludin Protein |
| Gene | OCLN |
| UniProt ID | Q16625 |
| Molecular Weight | 65.4 kDa |
| Subcellular Localization | Tight junctions of endothelial and epithelial cells |
| Protein Family | Occludin family |
Occludin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Occludin is a transmembrane tight junction protein that plays a critical role in maintaining blood-brain barrier function. It regulates paracellular permeability and protects the CNS from peripheral molecules [1].
Occludin is a 522 amino acid protein with:
N-terminus (148 aa)
|
[TM1]-[EC1]-[TM2]-[EC2]-[TM3]-[TM4]
|
C-terminus (150 aa)
Occludin is essential for BBB function:
Cummins, Occludin in barrier function (2012). Trends in Cell Biology.
Hawkins & Davis, The blood-brain barrier in neurodegeneration (2005). Pharmacology & Therapeutics.
Sweeney et al., Blood-brain barrier breakdown in Alzheimer's disease (2019). Nature Reviews Neurology.
The study of Occludin Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Cummins PM. "Occludin in barrier function." Trends in Cell Biology. 2012;22(2):75-77. DOI:10.1016/j.tcb.2012.01.002
Hawkins BT, Davis TP. "The blood-brain barrier/neurovascular unit in health and disease." Pharmacology & Therapeutics. 2005;107(1):1-11. DOI:10.1016/j.pharmthera.2005.01.004
Sweeney MD, Sagare AP, Zlokovic BV. "Blood-brain barrier breakdown in Alzheimer's disease and other neurodegenerative disorders." Nature Reviews Neurology. 2019;15(3):139-151. DOI:10.1038/s41582-019-0167-3