NOSTRIN interacts with neuronal nitric oxide synthase (nNOS) and affects its subcellular localization. It may regulate nitric oxide signaling in neurons. Dysregulation of NO signaling contributes to excitotoxicity and neurodegeneration.
| Attribute | Value |
|---|---|
| Protein Name | Nitric Oxide Synthase Trafficking Inducer |
| Gene | NOSTRIN |
| UniProt ID | Q9NRC8 |
| PDB ID | N/A |
| Molecular Weight | 58 kDa |
| Subcellular Localization | Cytoplasm, membrane |
| Protein Family | VPS10P domain receptors |
Nitric Oxide Synthase Trafficking Inducer is a VPS10P domain receptors protein involved in neuroprotection and neuronal function.
NOSTRIN interacts with neuronal nitric oxide synthase (nNOS) and affects its subcellular localization. It may regulate nitric oxide signaling in neurons. Dysregulation of NO signaling contributes to excitotoxicity and neurodegeneration.
NOSTRIN is implicated in endothelial dysfunction and may affect neurovascular unit function in neurodegeneration.
Research ongoing to understand NO signaling modulation.