Nos3 — Nitric Oxide Synthase 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| NOS3 | |
|---|---|
| Nitric Oxide Synthase 3 | |
| Gene Symbol | NOS3 |
| Full Name | Nitric Oxide Synthase 3 |
| Chromosome | 7q36 |
| NCBI Gene ID | [4846](https://www.ncbi.nlm.nih.gov/gene/4846) |
| Ensembl ID | [ENSG00000138771](https://www.ensembl.org/Homo_species/Gene/Summary?g=ENSG00000138771) |
| OMIM | [163729](https://www.omim.org/entry/163729) |
| UniProt ID | [Q9UHD5](https://www.uniprot.org/uniprot/Q9UHD5) |
| Associated Diseases | Alzheimer's Disease, Vascular Dementia, Stroke, Cardiovascular Disease |
| Expression | Endothelium, Brain, Platelets, Cardiomyocytes |
NOS3 (Nitric Oxide Synthase 3), also known as endothelial nitric oxide synthase (eNOS), is a gene located on chromosome 7q36 that encodes the endothelial isoform of nitric oxide synthase. This enzyme is primarily expressed in vascular endothelial cells where it produces nitric oxide (NO) that regulates blood flow, blood pressure, and vascular homeostasis.
NOS3 produces nitric oxide in endothelial cells:
NOS3 is distinct from NOS1 (neuronal) and NOS2 (indcible) isoforms in its regulation - it is constitutively expressed and primarily activated by calcium/calmodulin and phosphorylation.
NOS3 dysfunction may contribute to AD pathogenesis:
NOS3 is crucial for endothelial function:
NOS3 plays a role in BBB maintenance:
The study of Nos3 — Nitric Oxide Synthase 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.