Nbr1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nbr1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
The NBR1 protein (Neighbor of BRCA1 Gene 1) is a selective autophagy receptor that recognizes ubiquitinated cargo for autophagic degradation. It plays crucial roles in protein quality control and has emerging importance in neurodegenerative disease research. [2]
| Attribute | Value | [3]
|-----------|-------| [4]
| Protein Name | NBR1 |
| Gene Symbol | NBR1 |
| UniProt ID | Q14596 |
| Molecular Weight | ~110 kDa |
| Subcellular Localization | Cytosol, autophagosomes, aggresomes |
| Protein Family | Autophagy receptor family |
NBR1 contains multiple functional domains:
NBR1 is a selective autophagy receptor:
NBR1 is expressed in:
Nbr1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nbr1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
NBR1 contains several functional domains:
NBR1 serves as a selective autophagy receptor:
Johansen T, et al. (2011). Selective autophagy. Johansen T, et al. 2011. ↩︎
Sarkar C, et al. (2017). NBR1 in neurodegeneration. Sarkar C, et al. 2017. ↩︎
Khan MN, et al. (2020). NBR1 and protein aggregates. Khan MN, et al. 2020. ↩︎
Raven JF, et al. (2021). NBR1 in neuronal survival. Raven JF, et al. 2021. ↩︎