Nav1.9 Sodium Channel is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Nav1.9 (SCN11A) is a tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel predominantly expressed in nociceptive sensory neurons. It plays a critical role in pain signaling.
This protein is involved in:
| Attribute | Value |
|---|---|
| Protein Name | Nav1.9 (NaV1.9) |
| Gene | SCN11A |
| UniProt ID | Q9UQ10 |
| Molecular Weight | ~220 kDa |
| Subcellular Localization | Peripheral nerve terminals |
| Protein Family | Voltage-gated sodium channel (NaV) family |
Nav1.9 has the typical sodium channel architecture:
| Compound | Mechanism | Status | Notes |
|---|---|---|---|
| PF-01247424 | Nav1.9 blocker | Research | Selective blocker |
| Clinical candidates | Nav1.9 blocker | Preclinical | Under development |
The study of Nav1.9 Sodium Channel has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.