Scn11A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Scn11A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SCN11A (Sodium Voltage-Gated Channel Alpha Subunit 11) encodes the Nav1.9 sodium channel, a TTX-resistant channel important for pain signaling.
| Property | Value |
|---|---|
| Gene Symbol | SCN11A |
| Full Name | Sodium Voltage-Gated Channel Alpha Subunit 11 |
| Chromosomal Location | 3p21.2 |
| NCBI Gene ID | 6335 |
| Ensembl ID | ENSG00000170289 |
| UniProt | Q9UQ10 |
The SCN11A gene encodes Nav1.9, a TTX-resistant sodium channel:
| Disease | Association Type | Key Evidence |
|---|---|---|
| Chronic Pain | Therapeutic Target | Nav1.9 blockers under development for pain relief |
| Episodic Pain Syndrome | Causative | Gain-of-function mutations cause familial episodic pain |
| Small Fiber Neuropathy | Risk Modulator | SCN11A variants associated with SFN |
SCN11A shows specific expression:
Nav1.9 is a promising target for pain therapeutics:
| Compound | Type | Status | Notes |
|---|---|---|---|
| PF-01247424 | Blocker | Research | Selective Nav1.9 blocker |
| AM-2099 | Blocker | Research | Preclinical development |
Scn11A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Scn11A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Dib-Hajj SD, et al. Brain Res 2000;856:1-8