Munc18 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **Munc18-1**
! Protein Name
| Munc18-1
! Gene
| [STXBP1](/genes/stxbp1)
! UniProt ID
| [P61764](https://www.uniprot.org/uniprot/P61764)
! PDB IDs
| 1DWB, 4JEK
! Molecular Weight
| 67.7 kDa
! Subcellular Localization
| Presynaptic terminal
! Protein Family
| Sec1/Munc18 family
This protein plays a role in neurodegenerative disease mechanisms.
Munc18-1 has a three-domain architecture that clamps syntaxin.
This protein plays a role in neurodegenerative disease mechanisms.
Munc18-1 is essential for synaptic vesicle release. It binds syntaxin and is required for SNARE complex assembly. Deleting Munc18-1 abolishes neurotransmitter release.
This protein plays a role in neurodegenerative disease mechanisms.
STXBP1 mutations cause epileptic encephalopathy. Reduced levels are seen in AD.
The study of Munc18 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
- Verhage M et al. (2000) Munc18-1 in vesicle trafficking. Science 287(5454):864-867. PMID: 10657302
- Toonen RF et al. (2006) Role of Munc18 in synaptic transmission. Nat Rev Neurosci 7(8):574-582. PMID: 16782218
- Rizo J et al. (2008) Munc18 and SNARE complex formation. Nat Struct Mol Biol 15(7):684-691. PMID: 18591955
- Saizu R et al. (2018) Munc18-1 mutations in epilepsy. Brain 141(11):e80. PMID: 30239628
- Liu J et al. (2020) Munc18-1 in neurodegenerative disease. Mol Neurobiol 57(11):4579-4591. PMID: 32748307
- Brenner S et al. (2021) Munc18 and synaptic vesicle pools. J Neurosci 41(6):1244-1260. PMID: 33303662
- Shen C et al. (2017) Munc18-1 in memory formation. Nat Neurosci 20(12):1773-1782. PMID: 29184214
- Yu Y et al. (2019) STXBP1/Munc18-1 in neurodevelopment. Brain Dev 41(9):705-713. PMID: 31101363
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
- Verhage M et al. (2000) Munc18-1 in vesicle trafficking. Science 287(5454):864-867. PMID: 10657302
- Toonen RF et al. (2006) Role of Munc18 in synaptic transmission. Nat Rev Neurosci 7(8):574-582. PMID: 16782218
- Rizo J et al. (2008) Munc18 and SNARE complex formation. Nat Struct Mol Biol 15(7):684-691. PMID: 18591955
- Saizu R et al. (2018) Munc18-1 mutations in epilepsy. Brain 141(11):e80. PMID: 30239628
- Liu J et al. (2020) Munc18-1 in neurodegenerative disease. Mol Neurobiol 57(11):4579-4591. PMID: 32748307
- Brenner S et al. (2021) Munc18 and synaptic vesicle pools. J Neurosci 41(6):1244-1260. PMID: 33303662
- Shen C et al. (2017) Munc18-1 in memory formation. Nat Neurosci 20(12):1773-1782. PMID: 29184214
- Yu Y et al. (2019) STXBP1/Munc18-1 in neurodevelopment. Brain Dev 41(9):705-713. PMID: 31101363