MPV17 is a mitochondrial inner membrane protein involved in mitochondrial DNA maintenance. It forms a channel-like structure and is essential for mtDNA replication. MPV17 mutations cause mitochondrial DNA depletion syndrome with hepatic and neurological involvement.
MPV17 Protein is encoded by the MPV17 gene. It is a Mitochondrial inner membrane protein, mtDNA maintenance with a molecular weight of approximately 176 aa. The protein localizes to Mitochondrial inner membrane.
The MPV17 Protein contains characteristic domains for its function as a Mitochondrial inner membrane protein, mtDNA maintenance. Structural information is available from UniProt and the PDB.
MPV17 is a mitochondrial inner membrane protein involved in mitochondrial DNA maintenance. It forms a channel-like structure and is essential for mtDNA replication. MPV17 mutations cause mitochondrial DNA depletion syndrome with hepatic and neurological involvement.
Dysfunction of MPV17 Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of MPV17 Protein includes: