MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12), also known as DLK, is a serine/threonine kinase that regulates neuronal injury responses.
- Molecular weight: ~105 kDa
- Kinase domain: Serine/threonine
- Cellular localization: Cytoplasmic
MAP3K12/DLK:
- Axon injury signaling: Activates JNK pathway
- Synaptic plasticity: Modulates synaptic function
- ALS: Contributes to motor neuron degeneration
- Neuropathy: Mediates chemotherapy-induced
- Miller et al., DLK in axonal degeneration (2009)
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