Lrp3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
LRP3 (Low-Density Lipoprotein Receptor-Related Protein 3) is a member of the LDLR (Low-Density Lipoprotein Receptor) superfamily. LRP3 is a large transmembrane receptor involved in lipoprotein metabolism, cellular signaling, and neuronal function. While less characterized than other LRP family members (LRP1, LRP2/Megalin, LRP5, LRP6), LRP3 is expressed in the brain and has been implicated in Alzheimer's Disease (AD) and other neurodegenerative conditions. The protein is approximately 2,325 amino acids in length with a molecular weight of ~250 kDa. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Protein Name | Low-Density Lipoprotein Receptor-Related Protein 3 |
| Gene Symbol | LRP3 |
| UniProt ID | O75174 |
| Ensembl ID | ENSG00000141548 |
| Molecular Weight | ~250 kDa |
| Protein Length | 2,325 amino acids |
| Cellular Location | Plasma membrane, endosomes |
| Tissue Expression | Brain (cortex, hippocampus), heart, skeletal muscle |
| Protein Family | LDLR receptor family |
LRP3 contains characteristic LDLR family features:
LRP3 involvement in AD is emerging:
LRP3 interacts with:
Lrp3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Lrp3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.