| LRP3 — Low Density Lipoprotein Receptor-Related Protein 3 | |
|---|---|
| Symbol | LRP3 |
| Full Name | Low Density Lipoprotein Receptor-Related Protein 3 |
| Chromosome | 19q13.31 |
| NCBI Gene | 4037 |
| Ensembl | ENSG00000168434 |
| UniProt | O75174 |
| Gene Family | LDLR-related proteins |
| Expression | Brain, Heart, Skeletal Muscle |
Lrp3 — Low Density Lipoprotein Receptor Related Protein 3 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
LRP3 (Low Density Lipoprotein Receptor-Related Protein 3) is a member of the LDLR family that is expressed in the brain and other tissues. While less studied than LRP1 and LRP2, it plays roles in lipid metabolism and cellular signaling [1].
LRP3 functions as a receptor involved in endocytosis of lipoproteins and extracellular proteins. It contains ligand-binding repeats and is expressed in neuronal tissues, suggesting potential roles in brain function.
LRP3 is expressed in:
While direct evidence linking LRP3 to Alzheimer's disease is limited, its expression in the hippocampus and cortex suggests it may participate in neuronal signaling pathways relevant to neurodegeneration [2].
LRP3 variants have been studied in the context of:
Lrp3 — Low Density Lipoprotein Receptor Related Protein 3 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Lrp3 — Low Density Lipoprotein Receptor Related Protein 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1]</sup] Sugiyama, T. et al. (2000). LRP3, a new member of the low density lipoprotein receptor family. Journal of Biochemistry, 128(3), 439-445.
[2]</sup] Shinohara, M. et al. (2018). Role of LRP family in amyloid-beta clearance. Journal of Alzheimer's Disease, 62(3), 1027-1040.