Kcnq4 Protein Potassium Channel Kv7.4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNQ4 encodes the Kv7.4 potassium channel, a member of the KCNQ (KQT-like) family of voltage-gated potassium channels. This channel is prominently expressed in outer hair cells of the inner ear and in various neuronal populations, where it plays crucial roles in maintaining the resting membrane potential and regulating cellular excitability. [1]
| Property | Value | [2]
|----------|-------| [3]
| Protein Name | Potassium voltage-gated channel subfamily Q member 4 |
| Gene Symbol | KCNQ4 |
| UniProt ID | P56696 |
| Molecular Weight | ~75 kDa |
| Protein Length | 695 amino acids |
| Chromosomal Location | 1p34.3 |
The KCNQ4 channel has a typical voltage-gated potassium channel architecture:
| Strategy | Agent | Status |
|---|---|---|
| Retigabine | Ezogabine | Approved (withdrawn for epilepsy) |
| Flupirtine | D-18517 | Approved (analgesic) |
| Novel Activators | - | Clinical development |
The study of Kcnq4 Protein Potassium Channel Kv7.4 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.