Gsk3A Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GSK3A (GSK3A) is a serine/threonine-protein kinase that plays critical roles in neuronal signal transduction, synaptic plasticity, and protein phosphorylation. It is a key therapeutic target for Alzheimer's disease and other neurodegenerative disorders, with roles in tau phosphorylation, neuroinflammation, and cell survival pathways. [1]
GSK3A is a serine/threonine-protein kinase belonging to the glycogen synthase kinase (GSK) family. It plays critical roles in neuronal signal transduction, synaptic plasticity, and tau phosphorylation in Alzheimer's disease. [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | GSK3A (Glycogen Synthase Kinase 3 Alpha) | [5]
| Gene | GSK3A | [6]
| UniProt ID | P49840 | [7]
| Molecular Weight | 52.9 kDa |
| Subcellular Localization | Cytoplasm, Nucleus, Mitochondria |
| Protein Family | GSK-3 family |
| PDB Structure | 1H8F, 4NM3, 5K5N |
GSK3A is constitutively active in neurons and regulates:
GSK3A is a central player in AD pathogenesis:
| Compound | IC50 | Specificity | Development Stage |
|---|---|---|---|
| Tideglusib | 60 nM | GSK3A/B | Phase II |
| CHIR99021 | 10 nM | GSK3A/B | Research |
| AZD2858 | 68 nM | GSK3A/B | Phase I |
The study of Gsk3A Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
GSK3 family kinases in neurodegeneration: mechanisms and therapeutic potential. Nature Reviews Neuroscience. ↩︎
Tau phosphorylation by GSK3 isoforms in Alzheimer's disease pathogenesis. Neurobiology of Aging. ↩︎
Targeting GSK3 for neuroprotection in neurodegenerative diseases. Pharmacological Reviews. ↩︎
Lithium inhibition of GSK3 activity and therapeutic applications. Bipolar Disorders. ↩︎
GSK3 inhibitors in clinical trials for AD and related disorders. Current Alzheimer Research. ↩︎
Synaptic plasticity by GSK3 isoforms. Neuron. ↩︎
Neuroinflammation and GSK3 signaling in neurodegeneration. Journal of Neuroinflammation. ↩︎