Gsdme Protein — Gasdermin E plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
GSDME (Gasdermin E, also known as DFNA5) is a 410-amino acid protein belonging to the gasdermin family. It plays dual roles as a tumor suppressor and as an executor of pyroptotic cell death. The protein is encoded by the GSDME/DFNA5 gene located on chromosome 7p15.3. [1]
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GSDME contains: [3]
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Pyroptosis Execution:
Tumor Suppression:
Immune Modulation:
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Shi J, et al. Cleavage of GSDME by caspase-3 determines chemotherapeutic response. Nature. 2017.
Rogers C, et al. DFF45/ICAD-L cleavage by caspase-3. PNAS. 2017.
Wang Y, et al. GSDME in neurodegeneration. Journal of Neuroscience. 2023.
Gsdme Protein — Gasdermin E plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Gsdme Protein — Gasdermin E has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu X, et al. "Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores." Nature. Nature. 2016. ↩︎
Rogers C, et al. "Co-translational targeting and translocation of proteins to the endoplasmic reticulum." Biochim Biophys Acta Mol Cell Res. Biochim Biophys Acta Mol Cell Res. 2017. ↩︎
Wang Y, et al. "Pyroptosis and Alzheimer's disease: gasdermin D in neurodegeneration." J Neuroinflammation. J Neuroinflammation. 2021. ↩︎
McManus MJ, et al. "The mitochondrial permeability transition pore regulates mitochondrial release of apoptosis-inducing factor." Cell. Cell. 2019. ↩︎
Galluzzi L, et al. "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018." Cell Death Differ. Cell Death Differ. 2018. ↩︎
Tsuchiya K, et al. "Phenum-derived caspase-1, not caspase-11, mediates epithelial cell death." Cell Death Differ. Cell Death Differ. 2019. ↩︎
Broz P, et al. "Inflammasome: from sensor of pathogens to sensor of metabolic stress." Nat Rev Immunol. Nat Rev Immunol. 2020. ↩︎