Nr3A (Nmda Receptor Subunit) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | [1]
|---|---| [2]
| Protein Name | Glutamate Ionotropic Receptor NMDA Type Subunit 3A | [3]
| Gene Symbol | GRIN3A | [4]
| UniProt ID | Q9UQB5 |
| Molecular Weight | ~125 kDa |
| Subcellular Localization | Postsynaptic membrane, dendritic spines |
| Protein Family | Ionotropic glutamate receptor (NMDA-type) |
| Alternative Names | NR3A, GluN3A |
NR3A (GluN3A) is an atypical NMDA receptor subunit that forms unique receptor complexes with distinct properties. When combined with the obligatory GluN1 subunit, NR3A-containing receptors exhibit reduced magnesium sensitivity, altered conductance, and distinct pharmacological profiles. These receptors play critical roles in synaptic development, plasticity, and may influence neurodegenerative processes.
NR3A contains:
NR3A-containing receptors contribute to:
NR3A interacts with:
GRIN3A variants contribute to schizophrenia[1]:
NR3A in AD[2]:
GRIN3A may contribute to ALS pathogenesis[3]:
NR3A-containing receptors in stroke:
The study of Nr3A (Nmda Receptor Subunit) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu, J. et al. "NR3A in Alzheimer's disease." Journal of Alzheimer's Disease 2023; 91(4): 1423-1437. Journal of Alzheimer's Disease. 2023. ↩︎
Van De Velde, C. et al. "GRIN3A and ALS risk." Neurology 2021; 96(12): e1692-e1701. Neurology. 2021. ↩︎
Henson, M.A. et al. "NR3A-containing NMDA receptors in development." Developmental Neurobiology 2020; 80(4): 245-263. Developmental Neurobiology. 2020. ↩︎
Roberts, A.C. & J.M. "Glutamate receptors and brain function." Neuroscientist 2021; 27(5): 456-478. Neuroscientist. 2021. ↩︎