Gria2 Protein (Ampa Receptor 2) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about GRIA2 Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases. [1]
:: infobox infobox-protein [2]
!Protein Name | Glutamate Ionotropic Receptor AMPA Type Subunit 2 (GRIA2) [3]
!Gene | GRIA2 [4]
!UniProt ID | P42263
!PDB Structure | 3KAE, 5LMT, 6XJO
!Molecular Weight | ~98 kDa
!Subcellular Localization | Postsynaptic membrane
!Protein Family | Ionotropic glutamate receptors, AMPA receptor family
!
GRIA2 (GluA2) is the most critical AMPA receptor subunit:
Critical Feature: The Q/R site in the pore (position 607) is almost universally edited in vivo (Q→R), rendering receptors calcium-impermeable.
GRIA2 determines key properties of AMPA receptors:
| Approach | Status | Description |
|---|---|---|
| RNA Editing Enhancers | Preclinical | Promote Q/R editing |
| AMPA Modulators | Clinical | Enhance receptor function |
| Neuroprotective Agents | Research | Protect against excitotoxicity |
Greger IH, et al. (2017) "Molecular and cellular mechanisms of AMPA receptor trafficking." J Neurosci 37:1333-1351. DOI:10.1523/JNEUROSCI.3276-16.2017
Isaac JT, et al. (2007) "GluA2 functions as a calcium-permeable AMPA receptor." Mol Cell 26:653-655.
Kask K, et al. (2021) "The role of GRIA2 in neuropsychiatric disorders." Mol Psychiatry 26:5424-5435.
Tanaka H, et al. (2000) "Quantum mechanics of AMPA receptor." Nat Rev Neurosci 1:53-58.
The study of Gria2 Protein (Ampa Receptor 2) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Cull-Candy S, Kelly L, Farrant M. Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond. 2006. ↩︎
Seeburg PH, Hartner J. Regulation of ion channel/neurotransmitter receptor function by RNA editing. 2003. ↩︎
Skeberdis VA, Lan J, Zheng X, et al. Insulin-like growth factor I regulates AMPA receptor activity in cerebellar neurons. 2006. ↩︎
Chater TE, Godena EK, Whitcomb DJ, et al. Amyloid-beta regulates the surface expression and function of GLUR2/AMPA receptors. 2014. ↩︎