Gabrd Protein — Gaba A Receptor Delta Subunit plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Gabrd Protein — Gaba A Receptor Delta Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The GABA-A receptor δ subunit is primarily found in extrasynaptic receptors that mediate tonic inhibition. These receptors have a high affinity for GABA and contribute to the steady-state inhibition that controls neuronal excitability. The δ subunit-containing receptors are uniquely sensitive to neurosteroids like allopregnanolone and THDOC, which can potentiate their function at nanomolar concentrations. These receptors play critical roles in regulating network oscillations and may be important for neuroprotection.
| GABRD | |
|---|---|
| Protein Name | GABA-A Receptor Delta Subunit |
| Gene | GABRD |
| UniProt ID | O43513 |
| PDB IDs | 6X3S |
| Molecular Weight | 51 kDa |
| Subcellular Location | Cell membrane, Extrasynaptic |
| Protein Family | Cys-loop ligand-gated ion channel family |
The GABA-A receptor is a heteromeric pentameric chloride channel belonging to the Cys-loop ligand-gated ion channel superfamily. Each subunit consists of:
The GABRD subunit contributes to receptor pharmacology and subcellular targeting.
The GABA-A receptor GABRD is primarily associated with:
For γ2-containing receptors:
For δ-containing receptors:
Mutations in GABRD are associated with various forms of epilepsy:
GABA-A receptor dysfunction may contribute to:
GABRD-containing receptors are targets for:
Understanding GABRD structure aids in developing:
Gabrd Protein — Gaba A Receptor Delta Subunit plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Gabrd Protein — Gaba A Receptor Delta Subunit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Sigel E, et al. (2012). "Structure, function, and modulation of GABA(A) receptors." Journal of Biological Chemistry. DOI:10.1074/jbc.R112.386664
Olsen RW, et al. (2015). "GABA(A) receptors: subtypes, subunit composition, and physiologic function." Journal of Molecular Neuroscience. DOI:10.1007/s12031-015-0662-y