GABARAPL1 (GABA Receptor Associated Protein Like 1) is an autophagy-related protein involved in cellular clearance.
| GABARAPL1 (GABA Receptor Associated Protein-Like 1) | |
|---|---|
| Gene | [GABARAPL1](/genes/gabarapl1) |
| UniProt ID | [Q9Y4L1](https://www.uniprot.org/uniprot/Q9Y4L1) |
| PDB Structure | 1WJX, 5DC4, 6H3W (crystal/cryo-EM structures) |
| Molecular Weight | 14 kDa |
| Subcellular Localization | Cytosol, autophagosome, lysosome, nucleus |
| Protein Family | Atg8 family (MAP1LC3/GABARAP family) |
GABARAPL1 is a member of the Atg8 family of autophagy proteins[1]. The protein has a conserved ubiquitin-like fold:
GABARAPL1 is a multifunctional protein involved in autophagy and cellular homeostasis:
GABARAPL1 is critically involved in Alzheimer's disease pathogenesis:
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Chakrama, F.Z. et al. (2010). GABARAPL1: Autophagy and Beyond. Autophagy. 2010. ↩︎
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Spencer, B. et al. (2019). Beclin-1 Gene Therapy for Neurodegeneration. Molecular Therapy. 2019. ↩︎