p62/SQSTM1 Protein is a protein that p62/SQSTM1 is a multifunctional scaffold protein involved in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
The p62/SQSTM1 protein contains multiple functional domains:
p62/SQSTM1 is a multifunctional scaffold protein involved in:
p62 is crucial in ALS pathophysiology:
Johansen et al. The selective autophagy receptor p62 (SQSTM1). FEBS Journal. 2011. ↩︎
Komatsu et al. p62/SQSTM1: a hub for stress signaling. Cell Death and Differentiation. 2008. ↩︎
Giliberto et al. p62 in ALS pathogenesis. Molecular Neurodegeneration. 2018. ↩︎