Fzd9 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| FZD9 Protein | |
|---|---|
| Frizzled Class Receptor 9 | |
| Gene | FZD9 |
| UniProt ID | O00187 |
| PDB ID | 7D8K |
| Molecular Weight | 63,500 Da |
| Subcellular Localization | Plasma membrane |
| Protein Family | Frizzled receptor family |
FZD9 (Frizzled-9) is a seven-transmembrane receptor that activates canonical Wnt/β-catenin signaling. Located in the Williams syndrome deletion region, it plays important roles in brain development, learning, memory, and social behavior.
FZD9 activates β-catenin pathway:
Critical for:
FZD9 haploinsufficiency:
FZD9 in AD:
FZD9 interacts with:
The study of Fzd9 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.