Fzd8 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| FZD8 Protein | |
|---|---|
| Frizzled Class Receptor 8 | |
| Gene | FZD8 |
| UniProt ID | Q9H6Y5 |
| PDB ID | 6YAO |
| Molecular Weight | 63,900 Da |
| Subcellular Localization | Plasma membrane |
| Protein Family | Frizzled receptor family |
FZD8 (Frizzled-8) is a seven-transmembrane receptor that activates canonical Wnt/β-catenin signaling. It plays important roles in neural development, tissue patterning, and is frequently overexpressed in cancers.
FZD8 activates β-catenin pathway:
Regulates:
FZD8 in AD:
Overexpressed in:
FZD8 interacts with:
The study of Fzd8 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.