Fibroblast Growth Factor Receptor 4 (FGFR4) is a member of the FGFR family of receptor tyrosine kinases. It has distinct ligand specificity and has been implicated in cancer, metabolism, and recently in neurodegeneration.
FGFR4 (Fibroblast Growth Factor Receptor 4) is a receptor tyrosine kinase for FGF ligands. FGFR4 is expressed in various tissues including liver, lung, and brain. In the nervous system, FGFR4 regulates neural progenitor cell proliferation and differentiation. FGFR4 polymorphisms have been associated with neurodegenerative and cancer prognosis.
FGFR4 is a receptor tyrosine kinase:
FGFR4 binds FGF19, FGF21, and FGF23 with high affinity (endocrine FGFs).
FGFR4 has specific physiological roles:
Signaling activates RAS/MAPK, PI3K/AKT, PLCγ pathways.
FGFR4 modulation: