| FGF1 — Acidic Fibroblast Growth Factor | |
|---|---|
| Protein Name | FGF1 (aFGF) |
| Gene | [FGF1](/genes/fgf1) |
| UniProt ID | P05230 |
| Molecular Weight | ~17 kDa (155 amino acids) |
| Subcellular Localization | Cytoplasm, Extracellular space |
| Protein Family | FGF (Fibroblast Growth Factor) family |
| Structure | Beta-trefoil fold |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke |
Fgf1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
FGF1 (Acidic Fibroblast Growth Factor), also known as aFGF, is a member of the FGF family of growth factors. Encoded by the FGF1 gene, this protein is a potent neurotrophic factor that promotes neuronal survival, proliferation, and differentiation in the central and peripheral nervous systems [1][2].
FGF1 was the first growth factor of the FGF family to be characterized and remains one of the most studied neurotrophic factors for its potential therapeutic applications in neurodegenerative diseases [3].
FGF1 adopts a distinctive beta-trefoil structure consisting of:
Heparin-Binding Domain
Receptor-Binding Sites
FGF1 activates multiple FGFR isoforms:
Upon FGFR activation:
FGF1 in AD:
Neuroprotection
Neurogenesis
In PD:
FGF1 therapeutics:
The study of Fgf1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.