| FGF1 — Fibroblast Growth Factor 1 | |
|---|---|
| Symbol | FGF1 |
| Full Name | Fibroblast Growth Factor 1 (Acidic FGF) |
| Chromosome | 5q31.3 |
| NCBI Gene | 2246 |
| Ensembl | ENSG00000113578 |
| OMIM | 135500 |
| UniProt | P05230 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Stroke |
| Expression | Brain, Retina, Heart, Skeletal muscle, Adipose tissue |
FGF1 (Fibroblast Growth Factor 1), also known as acidic FGF (aFGF), is a member of the fibroblast growth factor family. Located on chromosome 5q31.3, FGF1 encodes a potent mitogen that plays crucial roles in development, tissue repair, and cellular survival [1][2].
FGF1 is one of the original members of the FGF family and binds to all four FGF receptor (FGFR) isoforms with varying affinity. In the nervous system, FGF1 exhibits neurotrophic and neuroprotective properties, making it a subject of interest for neurodegenerative disease research [3].
The FGF1 gene spans approximately 28 kb and consists of 3 non-coding exons (1A, 1B, 1C) and one coding exon. The gene produces multiple alternatively spliced transcripts encoding different N-terminal variants of the protein.
FGF1 is expressed in:
FGF1 binds to:
FGF1 binding activates:
In the nervous system, FGF1:
FGF1 is implicated in AD:
Neuroprotection
Neurogenesis
Expression Changes
In PD:
Dopaminergic Neurons
Therapeutic Potential
FGF1 has been studied in:
FGF1-based therapies:
Burgess et al., The structure of fibroblast growth factor (1990). Cell, 1990.
Reuss et al., Fibroblast growth factors in the central nervous system (2003). Progress in Brain Research, 2003.
Hoehn et al., Fibroblast growth factor in neurodegeneration (2002). Progress in Neurobiology, 2002.
Zhao et al., FGF1 and FGFR in Alzheimer's disease (2021). Journal of Alzheimer's Disease, 2021.
Turner et al., FGF1 neuroprotective effects in Parkinson's disease models (2018). Molecular Neurobiology, 2018.
FGF1 UniProt Entry P05230. UniProt, 2024.