Dync1Li1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{infobox .infobox-protein}}
| Property | Value |
|---|---|
| Protein Name | Dynein Cytoplasmic 1 Light Intermediate Chain 1 |
| Gene | DYNC1LI1 |
| UniProt ID | Q9Y4Q5 |
| PDB ID | 5EJ8, 5NTH |
| Molecular Weight | ~52 kDa |
| **Subcellular Localization |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
** | Cytoplasm, microtubules |
| Protein Family | Dynein light chain family |
DYNC1LI1 consists of:
The protein forms heterodimers with DYNC1LI2 and associates with the dynein heavy chain complex.
As a subunit of the cytoplasmic dynein-1 complex, DYNC1LI1:
Mutations in DYNC1LI1 cause a form of Charcot-Marie-Tooth disease type 2, characterized by peripheral neuropathy.
Dynein dysfunction contributes to:
Currently no direct therapeutic targeting of DYNC1LI1, but dynein modulators are under investigation for neurodegenerative diseases.
The study of Dync1Li1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.