Dync1H1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DYNC1H1 Protein (Cytoplasmic dynein 1 heavy chain 1) is the motor protein responsible for retrograde transport along microtubules in neurons. This large molecular motor moves cargo toward the minus end of microtubules, enabling transport from nerve terminals to cell bodies, and is essential for neuronal survival, synaptic function, and axonal maintenance.
| Attribute | Value |
|---|---|
| Protein Name | Dynein heavy chain 1 |
| Gene | DYNC1H1 |
| UniProt ID | Q9Y4G5 |
| Molecular Weight | ~532 kDa (massive multi-subunit complex) |
| Subcellular Localization | Microtubule minus ends, dendrites, axons |
| Protein Family | Dynein heavy chain family |
DYNC1H1 is one of the largest known proteins:
Dynein drives critical neuronal processes:
Dynein operates through:
Potential therapeutic strategies:
Vallee RB, et al. (2001) Cytoplasmic dynein. Annu Rev Cell Dev Biol 17:219-251. PMID:11687484
Hafezparast M, et al. (2003) DYNC1H1 mutations in Charcot-Marie-Tooth disease. Science 300(5627):1939-1942. PMID:12719698
Eschbach J, et al. (2021) DYNC1H1 and neurodegenerative disease. Nat Rev Neurol 17(5):265-280. PMID:33727732
King SJ, et al. (2000) Dynein motor function. Trends Cell Biol 10(3):85-88. PMID:10703676
Sharma N, et al. (2022) Axonal transport in neurodegeneration. Neuron 110(7):1117-1132. PMID:35148734
The study of Dync1H1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Vallee RB, et al. Cytoplasmic dynein. Annu Rev Cell Dev Biol 2001;17:219-251. PMID:11687484
Hafezparast M, et al. DYNC1H1 mutations in Charcot-Marie-Tooth disease. Science 2003;300(5627):1939-1942. PMID:12719698
Eschbach J, et al. DYNC1H1 and neurodegenerative disease. Nat Rev Neurol 2022;17(5):265-280. PMID:33727732
King SJ, et al. Dynein motor function. Trends Cell Biol 2000;10(3):85-88. PMID:10703676
Sharma N, et al. Axonal transport in neurodegeneration. Neuron 2022;110(7):1117-1132. PMID:35148734