Dynein Intermediate Chain Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Dynein Intermediate Chain Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Dynein Intermediate Chain Protein
| Protein Name | Dynein Intermediate Chain Protein |
| Gene | DYNC1I2 |
| UniProt ID | Q86X29 |
| PDB IDs | No PDB structures available |
| Molecular Weight | 71 kDa |
| Subcellular Localization | Cytoplasm |
| Protein Family | Dynein Light Intermediate Chain Family |
DYNC1I2 protein belongs to the Dynein Light Intermediate Chain Family. The protein localizes to Cytoplasm.
DYNC1I2 is a component of the cytoplasmic dynein complex, a motor protein that transports cargo along microtubules toward the minus end. It is essential for retrograde axonal transport.
Dynein dysfunction impairs axonal transport, leading to accumulation of organelles and proteins in neurons. This contributes to neurodegenerative diseases including Charcot-Marie-Tooth disease and spinal muscular atrophy.
No specific dynein-targeting drugs; microtubule-stabilizing agents are being investigated.
Dynein Intermediate Chain Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Dynein Intermediate Chain Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.