Dynactin Protein (Dctn1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | Dynactin Subunit 1 (p150-Glued) |
| Gene | DCTN1 |
| UniProt ID | Q14204 |
| PDB Structure | 3j1t, 5wjg |
| Molecular Weight | ~150 kDa (p150 subunit) |
| Subcellular Localization | Cytoplasm, axon, dendrites, synapses |
| Protein Family | Dynactin complex |
This protein plays a role in neurodegenerative disease mechanisms.
Dynactin subunit 1 (also known as p150-glued) is the largest subunit of the dynactin complex. The protein contains:
The p150 subunit forms a dimer that bridges the dynactin complex to cytoplasmic dynein.
This protein plays a role in neurodegenerative disease mechanisms.
In the nervous system, dynactin plays essential roles:
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
Mutations in DCTN1 cause familial ALS:
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
The study of Dynactin Protein (Dctn1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This protein plays a role in neurodegenerative disease mechanisms.
This protein plays a role in neurodegenerative disease mechanisms.
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