Dopamine Receptor D2 (Drd2) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about Dopamine Receptor D2, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases. [1]
:: infobox infobox-protein [2]
!Protein Name | Dopamine Receptor D2 (DRD2) [3]
!Gene | DRD2 [4]
!UniProt ID | P14416
!PDB Structure | 6CM4, 7R0H, 7VAB
!Molecular Weight | ~51 kDa (GPCR)
!Subcellular Localization | Cell membrane (GPCR), presynaptic terminals
!Protein Family | Dopamine receptor family (D2-like), GPCR class A
!
DRD2 exists in two primary splice variants:
Domain Organization:
The D2 receptor has higher affinity for dopamine than D1, allowing distinct signaling at lower dopamine concentrations.
DRD2 mediates inhibitory dopamine signaling:
| Drug Class | Examples | Primary Target |
|---|---|---|
| D2 Agonists | Pramipexole, Ropinirole | D2/D3 |
| D2 Partial Agonists | Aripiprazole | D2, 5-HT1A |
| Typical Antipsychotics | Haloperidol, Chlorpromazine | D2 |
| Atypical Antipsychotics | Risperidone, Clozapine | D2, 5-HT2 |
Beaulieu JM, Gainetdinov RR. (2011) "The physiology, signaling, and pharmacology of dopamine receptors." Pharmacol Rev 63:182-217. DOI:10.1124/pr.110.002642
Mailman R, et al. (2000) "Functional effects of dopamine receptor agonists." Adv Pharmacol 47:53-87.
Strange PG. (2008) "Signaling mechanisms of D2 dopamine receptors." Adv Pharmacol 55:37-52.
Seeman P. (2013) "Schizophrenia and dopamine receptors." Eur Neuropsychopharmacol 23:999-1009.
The study of Dopamine Receptor D2 (Drd2) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.