| Protein Name | Dopamine Receptor D1 |
|---|---|
| Gene | [DRD1](/genes/drd1) |
| UniProt ID | [P21728](https://www.uniprot.org/uniprot/P21728) |
| Molecular Weight | 49 kDa |
| Subcellular Localization | Plasma Membrane, [Dendritic Spines](/cell-types/dendritic-spines) |
| Protein Family | D1-like dopamine receptor family |
| Gene Location | 5q35.2 |
DRD1 (Dopamine Receptor D1) is the prototypical D1-like dopamine receptor and a critical mediator of dopaminergic signaling in the brain[1][2]. It is a G protein-coupled receptor (GPCR) that activates adenylate cyclase, increasing intracellular cAMP levels upon dopamine binding. DRD1 is highly expressed in the striatum, prefrontal cortex, and other brain regions involved in motor control, reward, and cognition[3]. Dysregulation of DRD1 signaling is implicated in Parkinson's disease, schizophrenia, and other neurological disorders.
DRD1 has characteristic GPCR features:
The receptor adopts the canonical GPCR fold with an orthosteric binding site accessible from the extracellular side[4].
DRD1 activates downstream signaling pathways:
DRD1 mediates diverse dopaminergic functions:
DRD1 modulates synaptic function:
DRD1 is central to PD and its treatment[5]:
DRD1 signaling affects AD pathogenesis:
DRD1 is a major therapeutic target:
D1 dopamine receptor: structure and function (2018). Nature Reviews Neuroscience. 2018. ↩︎
Dopamine receptors in CNS function (2020). Physiological Reviews. 2020. ↩︎
DRD1 in brain function and disease (2021). Brain Research Reviews. 2021. ↩︎
Structure of D1 dopamine receptor (2019). Nature. 2019. ↩︎
DRD1 and Parkinson's disease (2022). Movement Disorders. 2022. ↩︎