Dlg Associated Protein 1 (Sapap1) (Dlgap1 Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [1]
title: DLGAP1 Protein [2]
description: DLG Associated Protein 1 (SAPAP1) - Scaffolding protein in PSD, organizes synaptic protein complexes, anchors receptors [3]
tags: protein, neurodegeneration, SAPAP family [4]
--- [^6]
.infobox.inbox-protein [5]
DLGAP1 Protein [3:1]
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Protein Name: DLG Associated Protein 1 (SAPAP1)
Gene: DLGAP1
UniProt ID: O75178
Molecular Weight: 99 kDa
Protein Family: SAPAP family
Subcellular Localization: Postsynaptic density
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DLG Associated Protein 1 (SAPAP1) is a protein encoded by the DLGAP1 gene. It belongs to the SAPAP family and is primarily localized to Postsynaptic density.
DLGAP1 is a 99 kDa protein with multiple domains that enable its scaffolding and signaling functions in neurons.
Scaffolding protein in PSD, organizes synaptic protein complexes, anchors receptors. This protein plays important roles in maintaining normal neuronal function and synaptic transmission.
Alterations in DLGAP1 have been associated with several neurodegenerative and neurological disorders. Studies have shown changes in expression and mutations in various disease contexts.
Research is ongoing to develop therapeutic approaches targeting DLGAP1 for neurological disorders.
[1] https://pubmed.ncbi.nlm.nih.gov/10574462/
[2] https://pubmed.ncbi.nlm.nih.gov/10893236/
[3] https://pubmed.ncbi.nlm.nih.gov/11891228/
[4] https://pubmed.ncbi.nlm.nih.gov/15231748/
[5] https://pubmed.ncbi.nlm.nih.gov/19139271/
DLGAP1 serves as a critical scaffold at the postsynaptic density, mediating interactions between multiple synaptic proteins:
DLGAP1 plays a crucial role in activity-dependent synaptic plasticity:
The study of Dlg Associated Protein 1 (Sapap1) (Dlgap1 Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.