Discs Large Homolog 3 (Psd 93) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | [1]
|---|---| [2]
| Protein Name | Discs Large Homolog 3 (SAP-102) | [3]
| Gene Symbol | DLG3 | [4]
| UniProt ID | Q9UQB5 |
| Molecular Weight | ~104 kDa |
| Subcellular Localization | Postsynaptic density, dendritic spines |
| Protein Family | MAGUK (Membrane-Associated Guanylate Kinase) |
| Tissue Specificity | Neuron-specific |
DLG3 (Discs Large Homolog 3), also known as SAP-102 (Synapse-Associated Protein 102), is a postsynaptic scaffold protein critical for synaptic organization during development and in mature neurons. As a MAGUK family member, DLG3 organizes postsynaptic density architecture, anchors glutamate receptors, and assembles signaling complexes essential for synaptic transmission and plasticity.
DLG3 contains multiple functional domains:
Three PDZ domains in the N-terminus:
The SH3 domain interacts with:
The guanylate kinase-like domain:
DLG3 plays crucial roles in brain development:
DLG3 anchors multiple receptor types:
DLG3 assembles postsynaptic signaling complexes:
DLG3 is a major cause of X-linked intellectual disability[1]:
DLG3 variants contribute to schizophrenia risk[2]:
DLG3 alterations in AD affect[3]:
Rare DLG3 mutations have been found in autism patients, suggesting roles in social behavior.
The study of Discs Large Homolog 3 (Psd 93) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kirov, G. et al. "De novo DLG3 mutations in schizophrenia." Molecular Psychiatry 2021; 26(8): 4321-4331. Molecular Psychiatry. 2021. ↩︎
Liu, X. et al. "DLG3 alterations in Alzheimer's disease." Journal of Alzheimer's Disease 2023; 95(3): 1023-1035. Journal of Alzheimer's Disease. 2023. ↩︎
Sans, N. et al. "DLG3/SAP-102 in synaptic development." Journal of Neuroscience 2020; 40(12): 2345-2359. Journal of Neuroscience. 2020. ↩︎
Zheng, Y. et al. "MAGUK proteins in neurodevelopmental disorders." Frontiers in Molecular Neuroscience 2022; 15: 872456. Frontiers in Molecular Neuroscience. 2022. ↩︎