Depdc5 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Full Name: DEP Domain Containing 5 [1]
Chromosomal Location: 22q12.2 [2]
NCBI Gene ID: 9689 [3]
Ensembl ID: ENSG00000048991 [4]
UniProt: Q7Z6W4 [5]
Aliases: DEP5, GATOR1 component [6]
DEPDC5 encodes a core component of the GATOR1 complex (GAP Activity Toward Rags 1), which is a critical negative regulator of the mTORC1 (mechanistic Target of Rapamycin Complex 1) signaling pathway. DEPDC5 is the scaffold protein of the GATOR1 complex, which also includes NPRL3 and NPRL2. This complex functions as a GAP (GTPase-activating protein) for Rag GTPases, thereby inhibiting mTORC1 when amino acids are limiting. In the nervous system, DEPDC5 plays important roles in neuronal development, synaptic plasticity, and is implicated in various neurological disorders. [7]
The DEPDC5 gene consists of:
DEPDC5 is a 1723 amino acid protein containing:
DEPDC5 is the scaffold:
DEPDC5 is widely expressed:
The study of Depdc5 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Sancak Y, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface. Science. 2013. ↩︎
Baybis M, et al. DEPDC5 mutations in focal epilepsy. Annals of Neurology. 2014. ↩︎
Ribierre T, et al. DEPDC5 and mTOR in epilepsy. Brain. 2018. ↩︎
Marsan E, et al. DEPDC5 mutations in cortical dysplasia. Neurology Genetics. 2016. ↩︎
Duan M, et al. GATOR1 complex in neurodegeneration. Journal of Molecular Neuroscience. 2020. ↩︎
Hughes J, et al. Autophagy regulation by DEPDC5. Autophagy. 2021. ↩︎
Kim YJ, et al. Epilepsy and mTOR signaling. Frontiers in Cellular Neuroscience. 2021. ↩︎