Cyp2U1 Protein — Cytochrome P450 2U1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about CYP2U1 Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.
| Property | Value |
|---|---|
| Protein Name | CYP2U1 (Cytochrome P450 2U1) |
| Gene | CYP2U1 |
| UniProt ID | Q9Y5K1 |
| PDB ID | 5T7Q |
| Molecular Weight | 501 aa (~56 kDa) |
| Subcellular Localization | Endoplasmic reticulum membrane |
| Protein Family | Cytochrome P450 family |
CYP2U1 is a membrane-anchored cytochrome P450 with:
Key structural features:
CYP2U1 is a specialized cytochrome P450 that metabolizes:
CYP2U1 mutations cause HSP through:
CYP2U1-derived 20-HETE:
| Strategy | Approach | Status |
|---|---|---|
| 20-HETE inhibitors | Block 20-HETE synthesis | Preclinical |
| CYP2U1 siRNA | Reduce expression | Research |
| 20-HETE antagonists | Receptor blockade | Early development |
The study of Cyp2U1 Protein — Cytochrome P450 2U1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Expression data for CYP2U1 in the human brain can be explored through the following Allen Brain Atlas resources:
Tesson C, Nawara M, Salih MA, et al. Alteration of fatty-acid-metabolizing enzymes in autosomal recessive hereditary spastic paraplegia. 2012. ↩︎
Morikawa Y, Ishizaki M, Imaoka S, Funae Y. CYP2U1, a novel human cytochrome P450 expressed in brain and kidney. 2003. ↩︎
Kroetz DL, Zeldin DC. Cytochrome P450 pathways of arachidonic acid metabolism. 2002. ↩︎